"You Only Live Once" is song by American rock band the Strokes. It is the opening track on their third studio album "First Impressions of Earth". The song was written by Julian Casablancas with production from David Kahne and Gordon Raphael. It was released as the third and final single from the album on September 6, 2006 by RCA and Rough Trade Records. They have performed this song on several programs, including The Tonight Show with Jay Leno and Late Night with Conan O'Brien.

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