"Thuggish Ruggish Bone" is the 1994 debut single by American hip hop group Bone Thugs-n-Harmony, from their debut EP Creepin on ah Come Up. It features singer Shatasha Williams. The song reached #22 on the Billboard Hot 100. The song was included in the soundtrack of the video game True Crime: Streets of LA; and the second half of Layzie Bone's verse was reused on the track "Family Scriptures" on the Mo Thugs Family debut album, Family Scriptures.

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