Brandon Flowers' wife Tana suffers from anxiety and depression and was diagnosed with complex post-traumatic stress disorder following a difficult childhood. In 2015, Flowers canceled a string of tours for his solo album, The Desired Effect, after his wife's depression became severe, so he could go home to look after her. A number of songs on Wonderful Wonderful are about her condition. Flowers told UK's The Sun that writing personal songs such as "Rut" " Life To Come " and "Out of My Mind" has helped.

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