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“How to Fight Loneliness” is not, of course, a guide for fighting loneliness. The song is actually about how people pretend they are not lonely by smiling, laughing and showing that they’re having fun. The song was included in the soundtrack of the 1999 film Girl, Interrupted, the story of a group of girls being treated in a mental hospital in the late 1960s. In order to promote Girl, Interrupted, Wilco played “How to Fight Loneliness” live on Conan