"Do It to It" is the lead single from American girl group Cherish's 2006 debut album, Unappreciated. The track features rap/hip-hop artist Sean P. The song peaked at number 12 on the Billboard Hot 100 during its 16th week on the chart. It also reached number 15 on the Billboard Hot Digital Songs chart and number 8 on the Hot 100 Airplay chart. It had strong video play on BET and reached number 2 on 106 & Park. The song played for the limit of 65 days on the countdown and was eventually retired.

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