"A&E" was composed as a collaborative effort between Alison Goldfrapp and Will Gregory in 2007 in a recording studio near Somerset, England. Its lyrics were inspired by Goldfrapp's visit to the emergency department of a hospital on a Saturday afternoon. The doctors "pumped her up with loads of painkillers" and she described the situation as a "bit surreal." According to Goldfrapp, the song is a metaphor for a horrible relationship. The track describes Goldfrapp reflecting on a bad situation which resulted in an "accident and emergency."

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